Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) is an extraordinarily rare hematologic complication associated with COVID-19 vaccination. Symptoms may include persistent and severe headache, focal neurological findings, seizures, blurred vision, shortness of breath, chest or abdominal pain, swelling and redness in a limb or pallor and coldness in a limb. Onset may occur between 4-28 days after immunization (first or second vaccine). Laboratory findings may include thrombocytopenia, elevated D-dimer or imaging evidence of thrombosis.
In general, suspected VITT should be referred to a consulting Hematologist or Thrombosis physician who will oversee collection of required specimens in appropriate tubes, complete special laboratory requisitions and communicate with relevant reference laboratories. The consultant will take care of Connect Care orders (or will give the requesting physician specific instructions about which tests to order and how).
In sum, the important action for Connect Care prescribers is to order a Hematology consult and speak directly with the consultant.